Cravit 0.5% Ophthalmic Solution Mechanism of Action

Pharmacology: Levofloxacin, an optical isomer of ofloxacin (l-form), has 2 times more potent antibiotic activity than ofloxacin.
Mechanism of Action: The main mechanism of action of levofloxacin is to inhibit DNA gyrase activities of bacteria. Its effect is 2 times greater than that of ofloxacin. There was no difference between minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs), indicating its effect being bactericidal. Also bacteriolysis around MICs was shown in morphological observation.
Microbiology: Antibacterial Activity: Levofloxacin exerts a broad-spectrum potent antibacterial activity against organisms causing ophthalmological infections, including gram-positive bacteria [Staphylococcus sp, Streptococcus sp, (including S. pneumoniae), Micrococcus sp, Enterococcus sp, Corynebacterium sp, etc], gram-negative bacteria [Pseudomonas sp, (including P. aeruginosa), Haemophilus sp, Moraxella (Branhamella) catarrhalis, Moraxella sp, Serratia sp, Klebsiella sp, Proteus sp, Acinetobacter sp, etc] and anaerobic bacteria (Propionibacterium acnes, etc).
The antibacterial activity of levofloxacin against standard strains for each bacteria and clinically isolated bacteria identified in patients with external ocular infections was about twice as potent as that of ofloxacin (in vitro).
Effects on Experimental Pseudomonas aeruginosa Keratitis in Rabbits: Levofloxacin ophthalmic solution was effective in preventing experimental P. aeruginosa keratitis in rabbits.